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Friday, November 13, 2020 | History

2 edition of Effects of metabolizing enzyme modulators on chloral hydrate- and tribromoethanol-induced hepatotoxicity and analgesia. found in the catalog.

Effects of metabolizing enzyme modulators on chloral hydrate- and tribromoethanol-induced hepatotoxicity and analgesia.

Cleo Suk Kei Leung

Effects of metabolizing enzyme modulators on chloral hydrate- and tribromoethanol-induced hepatotoxicity and analgesia.

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Published .
Written in English


About the Edition

Chloral hydrate (CH) and tribromoethanol (TBOH) are anesthetics associated with hepatotoxicity. The metabolites and metabolizing enzymes responsible for anesthesia or toxicity are unknown. This thesis hypothesizes that trihaloethanols caused the anesthesia whereas trihaloacetaldehydes caused the toxicity. The effect of modulating metabolic enzymes in vitro (isolated rat hepatocytes) and in vivo (mice) were investigated. Ethanol reduced the hepatotoxicity of CH, trichloroethanol (TCOH), bromal and TBOH, and lengthened the anesthesia induced by CH and TCOH. This was prevented by inhibiting alcohol dehydydrogenase (ADH), indicating that the ADH-NADH-complex formed by ethanol reduced trihaloacetaldehydes to trihaloethanols. CYP3A induction increased hepatotoxicity and prevented anesthesia because CYP3A catalyzed the oxidation of trihaloethanols and trihaloacetaldehydes to form toxic free radicals. Cellular glutathione, the ferric chelator desferoxamine, and the antioxidant butylated hydroxyanisole prevented the lipid peroxidation, mitochondrial function disruption and hepatocytotoxicity. In conclusion, trihaloethanols caused anesthesia whereas trihaloacetaldehydes caused hepatotoxicity.

The Physical Object
Pagination93 leaves.
Number of Pages93
ID Numbers
Open LibraryOL19215265M
ISBN 100494022779


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Effects of metabolizing enzyme modulators on chloral hydrate- and tribromoethanol-induced hepatotoxicity and analgesia. by Cleo Suk Kei Leung Download PDF EPUB FB2